NDM 1, a big threat to human life

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The drug resistant bacteria has puzzled the minds of scientists since it cause antibiotic resistant infections in human body which makes antibiotics of no use. Bacteria which make NDM-1 are of growing concern to health professionals.NDM-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotic drugs. This is because it can inactivate most beta-lactam antibiotic drugs by hydrolyzing them. However, the structure of the protein which stops some of medicine’s most powerful antibiotics working has been determined by researchers.

The spreading and dissemination of NDM-1 positive strain has caused a serious threat to human health. The situation got worsened with cases being globally reported by Medias from countries including United States, Canada, Sweden, United Kingdom, Austria, Belgium, France, Netherlands, Germany, Africa, Oman, Australia, Japan and China. In a research, it has been found that Carbapenem antibiotics are considered the last line of defence against resistant bacteria. However, some are now resistant even to these drugs.

NDM-1 belonged to a class of enzymes which break down antibiotics. Most of these enzymes cannot attack carbapenems because their active sites – or jaws – are too small. However, NDM-1’s active site is a little bit bigger and can destroy carbapenems.NDM-1 is a serious threat to human health. The enzyme it carries is able to degrade many forms of antibiotic and render them useless,” said head researcher Simon Phillips of the Medical Research Council’s (MRC) research complex in Harwell, England. “In addition, the gene for NDM-1 can be passed between different bacteria so can spread rapidly in the population and generate drug resistance in different diseases.”

The need of the hour is to design a drug to inactivate NDM-1 so current drugs would work again or to create different antibiotics which are not susceptible to NDM-1. The first step towards designing such drug is the Identification of the structure of NDM-1. It is a crucial step towards ensuring that drug development is based on a sound understanding of the mechanisms of bacterial resistance to antibiotics. It can spread through renal or bone marrow transplantation, dialysis, cerebral infarction, chronic obstructive pulmonary disease, pregnancy, burns, road traffic accidents, and cosmetic surgery. Therefore, the spread of the pathogenic microorganisms carrying NDM-1 gene now becomes potentially a major global health threat. It is a serious issue which needs immediate attention so that it must not spread further.

Editor :   Health Filed under Healthcare.

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